The new show will very much stay in continuity, serving as a sequel to 2017's Blade Runner 2049, which in itself is a sequel to the 1982 original Blade Runner (all of which, of course, has been inspired by Philip K. Dick's Do Androids Dream of Electric Sheep).
Silka Luisa has been brought aboard to serve as writer and executive producer. She is currently the showrunner on Shining Girls, a drama starring Elisabeth Moss. Reportedly scripts are now being pulled together with the focus being on finding a production date to get things moving. The same reports note that Scott might direct episodes as well.
Beyond the previous installments mentioned above, Adult Swiim and Crunchroll debuted last year an anime series set in the universe titled Black Lotus. In it, Jessica Henwick voices a female replicant (one of the synethtic humans at the heart of Blade Runner in general).
Behind Blade Runner 2099 is Alcon Entertainment, which acquired franchise rights over a decade ago. They have been dedicated to expanding the universe, being sure to keep internal continuity intact.
Back in 1982, with the arrival of the first Blade Runner, Scott did an interview in which he detailed the notion behind the Replicants: "We deliberately stopped, in screenplay development, gong too far into the idea of genetic engineering, which we could have done. That would have been another, entirely different film ... So we drew a line: We wouldn't explore the laboratory details, the genetic explanations. Instead we'd ask: What if large combines in the next few decades became almost as powerful as the government? Which is possible. They'd move into all sorts of industries — arms, chemicals, aerospace — and eventually they'd go into genetics. And then you reach the point where genetics starts developing into the first 'man-made' man.
"From there," he added, "you can quite easily slip into breeding a second-class generation to do things which normally you or I wouldn't care to do, or psychologically couldn't stand to do. For instance, going into space knowing you're not going to come back. You take a humanoid and dick around with his brain, bring him along certain psychological lines, and he's going to go quite happily."
There's no word on when Blade Runner 2099 will actually go into production.